{"id":11966,"date":"2026-02-19T16:26:32","date_gmt":"2026-02-19T07:26:32","guid":{"rendered":"https:\/\/miragen.clinic\/atopic-dermatitis\/"},"modified":"2026-06-19T14:25:22","modified_gmt":"2026-06-19T05:25:22","slug":"atopic-dermatitis","status":"publish","type":"page","link":"https:\/\/miragen.clinic\/en\/atopic-dermatitis\/","title":{"rendered":"Atopic Dermatitis"},"content":{"rendered":"\n<div class=\"wp-block-group has-custom-color-1-color has-text-color has-link-color wp-elements-f62dd9b9ef310d7070799f9445ced999 has-global-padding is-layout-constrained wp-container-core-group-is-layout-8060a47a wp-block-group-is-layout-constrained\" style=\"margin-top:0px;padding-top:240px;padding-right:var(--wp--preset--spacing--superbspacing-small);padding-bottom:240px;padding-left:var(--wp--preset--spacing--superbspacing-small)\">\n<p class=\"has-custom-color-6-color has-text-color has-link-color wp-elements-637eeb30a61609d8739a5c5fa7780e5b wp-block-paragraph\">Conditions<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-left has-custom-color-1-color has-text-color has-link-color wp-elements-b8f66c351b3cf9c7e1f2a8b77e7cccd5\" id=\"&#xC544;&#xD1A0;&#xD53C;-&#xC65C;-&#xC0DD;&#xAE30;&#xACE0;-&#xC5B4;&#xB5BB;&#xAC8C;-&#xCE58;&#xB8CC;&#xD574;&#xC57C;-&#xD560;&#xAE4C;&#xC694;\">Atopic Dermatitis | Why does it occur and how is it treated?<\/h1>\n\n<\/div>\n\n<div class=\"wp-block-group has-custom-color-2-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-353751c3 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--superbspacing-xlarge);padding-right:var(--wp--preset--spacing--superbspacing-small);padding-bottom:var(--wp--preset--spacing--superbspacing-xlarge);padding-left:var(--wp--preset--spacing--superbspacing-small)\">\n<div class=\"wp-block-rank-math-toc-block has-custom-color-5-color has-custom-color-11-background-color has-text-color has-background has-link-color wp-elements-e59ffda3d8c5a7e7afae662a780f6116\" style=\"padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:0;padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:0\" id=\"rank-math-toc\"><h2>Table of Contents<\/h2><nav><ul><li class=\"\"><a href=\"#sec-1\">1. Causes of Atopic Dermatitis<\/a><\/li><li class=\"\"><a href=\"#sec-2\">2. Atopic Dermatitis, Rosacea, and Seborrheic Dermatitis: What are the differences?<\/a><\/li><li class=\"\"><a href=\"#sec-3\">3. Atopic Dermatitis and Allergies<\/a><\/li><li class=\"\"><a href=\"#sec-4\">4. Atopic Dermatitis and Food<\/a><\/li><li class=\"\"><a href=\"#sec-5\">5. Steroid Ointments<\/a><\/li><li class=\"\"><a href=\"#sec-6\">6. Protopic and Elidel<\/a><\/li><li class=\"\"><a href=\"#sec-7\">7. Antihistamines<\/a><\/li><li class=\"\"><a href=\"#sec-8\">8. Moisturizers<\/a><\/li><li class=\"\"><a href=\"#sec-9\">9. Managing Irritants in Daily Life<\/a><\/li><li class=\"\"><a href=\"#sec-10\">10. Our Clinic&#8217;s Treatment Policy<\/a><\/li><li class=\"\"><a href=\"#sec-conclusion\">Conclusion<\/a><\/li><li class=\"\"><a href=\"#\uc790\uc8fc-\ubb3b\ub294-\uc9c8\ubb38\">Frequently Asked Questions<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-1\">1. Causes of Atopic Dermatitis<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Atopic dermatitis is a condition that occurs when <strong>the skin barrier is weak<\/strong>, allowing <strong>external irritants to penetrate the skin<\/strong>.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18329087\/\" target=\"_blank\" rel=\"noopener\">1<\/a><\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Congenital or acquired <strong>barrier defects are the starting point<\/strong>. As the barrier breaks down, the <strong>immune response becomes overactivated<\/strong>, leading to a vicious cycle where the overactive immunity further weakens the barrier.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18329087\/\" target=\"_blank\" rel=\"noopener\">1<\/a><\/sup> In this process, <strong>atopic dermatitis can also trigger immune abnormalities (allergies)<\/strong>.<\/p>\n\n\n\n<figure class=\"wp-block-image alignwide size-full\"><img decoding=\"async\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/06\/skin-barrier-damage-irritant-penetration_en.png\" alt=\"An infographic explaining the fundamental cause of dermatitis using a brick wall analogy &#x2014; a healthy skin barrier blocks external irritants, while a damaged skin barrier allows irritants to penetrate through cracks, triggering atopic dermatitis.\" class=\"wp-image-4749\" title=\"Principles of Skin Barrier Damage\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Pediatric Atopic Dermatitis<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Atopic dermatitis is common in children because <strong>their skin barrier is immature and vulnerable to external irritants<\/strong>. In particular, <strong>if there is a filaggrin gene mutation, the barrier is even more fragile<\/strong>, significantly increasing the risk of onset.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16550169\/\" target=\"_blank\" rel=\"noopener\">2<\/a><\/sup> If you are unsure whether a rash on a baby&#8217;s face is heat rash or atopic dermatitis, please refer to our article on <a href=\"https:\/\/miragen.clinic\/blog\/%ec%8b%a0%ec%83%9d%ec%95%84-%ec%95%84%ed%86%a0%ed%94%bc-%ed%83%9c%ec%97%b4\/\" data-type=\"post\" data-id=\"3370\">Distinguishing Newborn Atopic Dermatitis from Heat Rash<\/a>. <\/p>\n\n\n\n<figure class=\"wp-block-image alignwide size-large\"><img decoding=\"async\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/06\/atopy_child_adult_barrier_comparison_en.png\" alt=\"An infographic comparing pediatric and adult skin barriers to a brick wall; it explains that atopic dermatitis is common in children because irritants easily pass through their immature barriers, while adults have a strong barrier that blocks irritants.\" class=\"wp-image-4540\" title=\"Comparison of Pediatric and Adult Skin Barriers\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Adult Atopic Dermatitis<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In most cases, atopic dermatitis disappears as the skin barrier matures in adulthood. However, if the skin barrier is damaged by <strong>peels, lasers, waxing, home care devices, functional cosmetics (such as AHA\/BHA\/Retinol), steroid misuse<\/strong>, or occupational exposure to chronic irritants, atopic dermatitis can recur or develop for the first time. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-2\">2. Atopic Dermatitis, Rosacea, and Seborrheic Dermatitis: What are the differences?<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">All three conditions share the commonality that <strong>the skin barrier is weak, making contact dermatitis prone to occur<\/strong> even from everyday irritants. In addition, each condition has its own unique aggravating factors. <\/p>\n\n\n\n<ul class=\"wp-block-list has-custom-color-5-color has-text-color has-link-color wp-elements-9b88ea937efbe21d2934bb8b529a1ed4\">\n<li><strong>Atopic Dermatitis<\/strong> \u2014 Immune hypersensitivity reaction caused by the penetration of allergens (house dust mites, pollen, etc.)<\/li>\n\n\n\n<li><strong>Rosacea<\/strong> \u2014 Vasodilation and inflammation caused by the penetration of Demodex mite metabolites<\/li>\n\n\n\n<li><strong>Seborrheic Dermatitis<\/strong> \u2014 Inflammation caused by the penetration of Malassezia fungal metabolites<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Since the fundamental cause is the same, the <strong>treatment principle of requiring barrier recovery is also shared<\/strong>. However, because the additional treatments tailored to each condition differ, an accurate diagnosis is crucial. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detailed information on each condition can be found in the <a href=\"https:\/\/miragen.clinic\/%ec%a3%bc%ec%82%ac%ed%94%bc%eb%b6%80%ec%97%bc\/\">Rosacea Guide<\/a> and the <a href=\"https:\/\/miragen.clinic\/%ec%a7%80%eb%a3%a8%ec%84%b1%ed%94%bc%eb%b6%80%ec%97%bc\/\">Seborrheic Dermatitis Guide<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-image alignwide size-large\"><img decoding=\"async\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/06\/atopy_rosacea_seborrheic_dermatitis_comparison_en.png\" alt=\"An infographic comparing atopic dermatitis, rosacea, and seborrheic dermatitis; it shows that while all three begin with skin barrier damage, the primary aggravating factors differ: allergens for atopic dermatitis, Demodex for rosacea, and Malassezia for seborrheic dermatitis.\" class=\"wp-image-4395\" title=\"Comparison Infographic of the Three Conditions\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-3\">3. Atopic Dermatitis and Allergies<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Many people misunderstand atopic dermatitis as an allergic disease, but conversely, <strong>atopic dermatitis triggers allergies<\/strong>.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18539191\/\" target=\"_blank\" rel=\"noopener\">3<\/a>,<a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22293182\/\" target=\"_blank\" rel=\"noopener\">4<\/a><\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">3.1 Citizens and the Mafia<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Our immune system recognizes substances that first enter through the <strong>&#8216;<\/strong>front gate&#8217; (digestive or respiratory tract) as citizens (immune tolerance).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, if the &#8216;fence&#8217; (skin) is broken, some substances enter through the gaps first. In this case, the immune system recognizes those substances as the &#8216;Mafia.&#8217; <\/p>\n\n\n\n<figure class=\"wp-block-image alignwide size-large\"><img decoding=\"async\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/06\/atopic_dermatitis_allergic_march_en.png\" alt=\"An infographic explaining the relationship between atopic dermatitis and allergies using the Citizen\/Mafia analogy; it visualizes the immune principle where food entering through the mouth is recognized as a citizen, while food entering through gaps in a broken skin barrier is recognized as the Mafia.\" class=\"wp-image-4545\" title=\"Causes and Consequences of Allergies\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"undefined-1\">3.2 The Emergency Alarm<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Once a substance is labeled as the Mafia, an emergency alarm (inflammation) rings throughout the body even if it enters through the front gate (food or respiration).<\/p>\n\n\n\n<figure class=\"wp-block-image alignwide size-full\"><img decoding=\"async\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/06\/atopy_allergen_immune_alarm_en.png\" alt=\"An illustration depicting milk and peanuts, once recognized as the Mafia, entering through the mouth wearing burglar masks and triggering an immune alarm; it explains the process of how food allergies spread systemically after skin barrier damage.\" class=\"wp-image-4544\" title=\"Mechanism of Allergen Immune Response\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"undefined-2-1\">3.3 The Core of Treatment<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Therefore, for atopic dermatitis accompanied by allergies, <strong>efforts to identify and avoid environmental allergens are necessary<\/strong>, in addition to skin care.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"undefined-3\">3.4 Atopic Dermatitis Without Allergies<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">However, not all atopic dermatitis is accompanied by allergies. It is called extrinsic if <strong>accompanied by allergies<\/strong>, and <strong>intrinsic if it is not<\/strong>.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Characteristics of Intrinsic Atopic Dermatitis<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Intrinsic cases account for approximately 20% of all atopic dermatitis<\/strong> and are characterized by <strong>normal serum IgE levels<\/strong> during <a href=\"https:\/\/miragen.clinic\/%ec%95%8c%eb%a0%88%eb%a5%b4%ea%b8%b0-%ea%b2%80%ec%82%ac\/\">acute allergy testing (MAST test)<\/a>, with no sensitization to environmental allergens.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11551248\/\" target=\"_blank\" rel=\"noopener\">5<\/a><\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This occurs because the skin barrier issues developed after the list of Citizens and Mafia had already been finalized; therefore, it is not accompanied by allergies.<\/p>\n\n\n\n<figure class=\"wp-block-image alignwide size-full\"><img decoding=\"async\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/06\/intrinsic_atopy_immune_tolerance_mechanism_en.png\" alt=\"A scene where milk and peanuts, already recognized as citizens, do not trigger an immune alarm even when entering through gaps in the broken skin barrier; it metaphorically explains the cause of intrinsic atopic dermatitis that is not accompanied by allergies.\" class=\"wp-image-4531\" title=\"Principle of Intrinsic Atopy Without Allergies\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Because the immune system ignores external substances entering through the fence, thinking &#8220;It&#8217;s just a citizen,&#8221; there are many cases where <strong>the damage to the fence is severe compared to the symptoms<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, since one can focus on repairing the broken fence rather than environmental management, <strong>treatment is generally easier<\/strong> than in cases accompanied by allergies (extrinsic).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-4\">4. Atopic Dermatitis and Food<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">The relationship between atopic dermatitis and food differs significantly between children and adults.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Since childhood is a period when the immune system learns to react to food, it is more important to establish <strong>immune tolerance<\/strong> by introducing a variety of foods early on, rather than imposing indiscriminate dietary restrictions, unless there is a severe allergic reaction.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25705822\/\" target=\"_blank\" rel=\"noopener\">6<\/a><\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Adults are not as affected by food as children, but caution is needed as foods high in histamine, foods high in nickel (if a nickel allergy exists), sugar, and alcohol can worsen symptoms.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24688624\/\" target=\"_blank\" rel=\"noopener\">7<\/a><\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detailed information on foods good for atopic dermatitis (probiotics, Vitamin D), foods to avoid, and the effects of sugar, flour, dairy, and caffeine has been organized by evidence level in the blog post below.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud83d\udc49 <a href=\"https:\/\/miragen.clinic\/blog\/%ec%95%84%ed%86%a0%ed%94%bc%ec%97%90-%ec%a2%8b%ec%9d%80-%ec%9d%8c%ec%8b%9d\/\">Foods Good for Atopic Dermatitis, Foods to Avoid | Differences Between Children and Adults, Sugar and Flour<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Information regarding delayed-type allergy testing (IgG4) can be found in the <a href=\"https:\/\/miragen.clinic\/%ec%a7%80%ec%97%b0%ec%84%b1-%ec%95%8c%eb%9f%ac%ec%a7%80-%ea%b2%80%ec%82%ac\/\">Delayed Allergy Test Guide<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-5\">5. Steroid Ointments<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Steroid ointments can suppress inflammation quickly and powerfully, but they can also weaken the skin barrier. Therefore, they must be used carefully, considering the potency grade, application site, and barrier condition.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25396122\/\" target=\"_blank\" rel=\"noopener noreferrer\">8<\/a><\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Basic usage instructions and precautions for steroid ointments can be found in the <a href=\"https:\/\/miragen.clinic\/%ec%8a%a4%ed%85%8c%eb%a1%9c%ec%9d%b4%eb%93%9c-%ec%99%b8%ec%9a%a9%ec%a0%9c\/\">Topical Steroid Guide<\/a>, and a list of products by grade is available in the <a href=\"https:\/\/miragen.clinic\/blog\/%ec%8a%a4%ed%85%8c%eb%a1%9c%ec%9d%b4%eb%93%9c-%ec%97%b0%ea%b3%a0-%eb%93%b1%ea%b8%89\/\">Steroid Ointment Grades<\/a> article.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-6\">6. Protopic and Elidel<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Protopic and Elidel are non-steroidal anti-inflammatory agents that can be used instead of steroids. They are useful in situations requiring long-term management, such as atopic dermatitis, because they do not weaken the skin barrier.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21974750\/\" target=\"_blank\" rel=\"noopener noreferrer\">9<\/a><\/sup> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, when the skin barrier is weak, excessive absorption can lead to contact dermatitis; therefore, it is advisable to check sensitivity with a <a href=\"https:\/\/miragen.clinic\/%ec%b2%a9%ed%8f%ac-%ea%b2%80%ec%82%ac\/\">patch test<\/a> before use.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detailed information can be found in the <a href=\"https:\/\/miragen.clinic\/%ec%97%98%eb%a6%ac%eb%8d%b8\/\">Elidel Guide<\/a> and the <a href=\"https:\/\/miragen.clinic\/%ed%94%84%eb%a1%9c%ed%86%a0%ed%94%bd\/\">Protopic Guide<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-7\">7. Antihistamines<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Many patients with atopic dermatitis take antihistamines to reduce itching. However, to date, there is no high-level evidence that antihistamines directly reduce the itching associated with this condition. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The itch of atopic dermatitis is different from that of hives.<\/strong> The itch of hives is driven by histamine, so antihistamines work well.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, the itch of atopic dermatitis is driven by pathways such as IL-31 and TSLP, rather than histamine.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24094650\/\" target=\"_blank\" rel=\"noopener\">10<\/a><\/sup> Blocking only the histamine pathway with antihistamines does not reach the root cause of the itch.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In fact, two Cochrane Systematic Reviews failed to demonstrate consistent effects on itching for both antihistamine monotherapy<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23450580\/\" target=\"_blank\" rel=\"noopener\">11<\/a><\/sup> and add-on therapy<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30666626\/\" target=\"_blank\" rel=\"noopener\">12<\/a><\/sup>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, in a study directly comparing sedative (1st generation) and non-sedative (2nd generation) antihistamines, <strong>neither drug showed a difference in itch intensity compared to a placebo.<\/strong><sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2110817\/\" target=\"_blank\" rel=\"noopener\">13<\/a><\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"7-1-&#xADF8;&#xB7EC;&#xBA74;-&#xC65C;-&#xCC98;&#xBC29;&#xB418;&#xB294;-&#xAC78;&#xAE4C;&#xC694;\">7.1 Then why are they prescribed?<\/h3>\n\n\n\n<figure class=\"wp-block-image alignwide size-large\"><img decoding=\"async\" width=\"1024\" height=\"686\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/02\/1st-generation-antihistamine-pheniramine.png\" alt=\"Pheniramine, a 1st-generation antihistamine prescribed for nocturnal pruritus in atopic dermatitis &#x2014; it does not reduce the itch itself but helps with sleep through its sedative effect, indirectly reducing nighttime scratching.\" class=\"wp-image-4665\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">1st-generation (sedative) antihistamines block histamine receptors in the brain, <strong>inducing drowsiness<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Since itching often worsens at night, the sedative effect of antihistamines <strong>helps with sleep and indirectly assists in reducing nighttime scratching<\/strong>.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10606058\/\" target=\"_blank\" rel=\"noopener\">14<\/a><\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In other words, antihistamines <strong>do not reduce the itch itself, but rather reduce scratching by putting the patient to sleep<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The American Academy of Dermatology (AAD), European guidelines (EuroGuiDerm), and Korean guidelines all state that the general use of antihistamines is not recommended, and only short-term nighttime use of sedative (1st generation) types for sleep assistance may be considered.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26512171\/\" target=\"_blank\" rel=\"noopener\">15<\/a><\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Since 2nd-generation (non-sedative) antihistamines do not induce drowsiness and fail to reduce itching, there is no evidence to support prescribing them for the purpose of relieving itch.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-8\">8. Moisturizers<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Moisturizers support the function of the skin barrier, reducing water evaporation and blocking external irritants. However, when the skin barrier is weak, moisturizer ingredients can be absorbed excessively and may actually cause irritation; therefore, it is important to find a suitable moisturizer.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16815133\/\" target=\"_blank\" rel=\"noopener noreferrer\">16<\/a>,<a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30053491\/\" target=\"_blank\" rel=\"noopener noreferrer\">17<\/a><\/sup> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you suspect a moisturizer is causing irritation, it is helpful to stop moisturizing for about 3 days (zero-moisturizing). The principles and criteria for zero-moisturizing can be found in the <a href=\"https:\/\/miragen.clinic\/blog\/%eb%85%b8%eb%b3%b4%ec%8a%b5\/\">Zero-Moisturizing Treatment<\/a> article. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For more details on moisturizer selection criteria and MD creams, please refer to the <a href=\"https:\/\/miragen.clinic\/md-%ed%81%ac%eb%a6%bc\/\">MD Cream Guide<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-9\">9. Managing Irritants in Daily Life<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"9-1-&#xC138;&#xD0C1;-&#xC138;&#xC81C;&#xC640;-&#xC12C;&#xC720;&#xC720;&#xC5F0;&#xC81C;\">9.1 Laundry Detergents and Fabric Softeners<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Detergent residue and fabric softeners left on clothes worn daily and blankets used overnight gradually break down the skin barrier.<sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35759448\/\" target=\"_blank\" style=\"color: inherit;\" rel=\"noopener\">18<\/a><\/sup><\/p>\n\n\n\n<ul class=\"wp-block-list has-custom-color-5-color has-text-color has-link-color wp-elements-3fb8ba66a0d711f1389a4c05e6306019\">\n<li><strong>Avoid using fabric softeners if possible:<\/strong> The principle of fabric softeners is to coat the fiber surface with a film of &#8216;fragrance&#8217; and &#8216;chemical components.&#8217; These ingredients cause continuous irritation to the skin. <\/li>\n\n\n\n<li><strong>Liquid Detergent + Fragrance-free\/Dye-free:<\/strong> Liquid detergents, which dissolve well in water, leave less residue than powder detergents. We recommend products that are &#8216;free of fragrances and dyes&#8217; rather than those that &#8216;smell good.&#8217; <\/li>\n\n\n\n<li><strong>Sufficient Rinsing:<\/strong> You should add 1\u20132 extra rinse cycles beyond the washing machine&#8217;s default setting to completely remove residual detergent components.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image alignwide size-large\"><img decoding=\"async\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/06\/laundry_detergent_skincare_guide_en.png\" alt=\"A laundry guide infographic for dermatitis patients, providing three lifestyle improvement methods with illustrations: avoiding fabric softeners, choosing fragrance-free liquid detergents, and adding 1&#x2013;2 extra rinses.\" class=\"wp-image-4538\" title=\"Laundry Detergent Management Guide\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"9-2-&#xD5A5;&#xC218;&#xC640;-&#xD5A5;&#xB8CC;\">9.2 Perfumes and Fragrances<\/h3>\n\n\n\n<ul class=\"wp-block-list has-custom-color-5-color has-text-color has-link-color wp-elements-f93f43f82f96828273f6602a85897132\">\n<li><strong>The Main Culprit of Contact Dermatitis: Perfume<\/strong> is one of the most common causes of allergic contact dermatitis.<sup><a style=\"color: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25207685\/\" target=\"_blank\" rel=\"noopener\">19<\/a><\/sup> Not only perfumes, but also fragrance components floating in the air from diffusers and room sprays can settle on the skin and cause irritation.<\/li>\n\n\n\n<li><strong>No Direct Application:<\/strong> When the skin barrier is unstable, you must absolutely avoid spraying perfume directly onto the skin. If you want a scent, consider alternatives such as using a small amount on clothes or the ends of your hair instead of the skin. <\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image alignwide size-large\"><img decoding=\"async\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/06\/fragrance_precaution_for_dermatitis_patients_en.png\" alt=\"An infographic on perfume and fragrance precautions for dermatitis patients, introducing perfumes, diffusers, and room sprays as major causes of contact dermatitis and recommending application on clothes or hair instead of direct skin contact.\" class=\"wp-image-4549\" title=\"Precautions for Perfumes and Fragrances\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"9-3-&#xADF8;-&#xC678;&#xC758;-&#xC0DD;&#xD65C;-&#xC2B5;&#xAD00;\">9.3 Other Lifestyle Habits<\/h3>\n\n\n\n<ul class=\"wp-block-list has-custom-color-5-color has-text-color has-link-color wp-elements-445677995b9be88a61b1f4e4954c8877\">\n<li><strong>Minimize Cosmetics:<\/strong> It is best to refrain from using sunscreen or cosmetics until the skin barrier is fully recovered. They can seep into the skin and worsen inflammation. <\/li>\n\n\n\n<li><strong>Watch Your Body Temperature:<\/strong> Increased body temperature from alcohol, spicy food, saunas, baths, or hot showers can increase blood flow to the skin and worsen inflammation.<\/li>\n\n\n\n<li><strong>Proper Cleansing and Showering:<\/strong> It is very important to wash off irritants on the skin. Be sure to wash your face and shower every morning and evening, and wash immediately if exposed to external irritants. However, harsh cleansers or hot water will further break down the barrier. If the barrier is significantly weakened, focus on washing with water and use lukewarm water.   <\/li>\n\n\n\n<li><strong>Masks and Air Purifiers:<\/strong> If you have allergies to respiratory antigens, wear a mask when going out and run an air purifier indoors to minimize allergen exposure.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-10\">10. Our Clinic&#8217;s Treatment Policy<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">We consider <strong>the recovery of the skin barrier to be more important<\/strong> than simply suppressing inflammation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To achieve this, we provide guidance on lifestyle habits to reduce external irritation after performing <a href=\"https:\/\/miragen.clinic\/%ec%95%8c%eb%a0%88%eb%a5%b4%ea%b8%b0-%ea%b2%80%ec%82%ac\/\">MAST tests<\/a>, <a href=\"https:\/\/miragen.clinic\/%ec%b2%a9%ed%8f%ac-%ea%b2%80%ec%82%ac\/\">patch tests<\/a>, and <a href=\"https:\/\/miragen.clinic\/tewl-%ea%b2%80%ec%82%ac\/\">skin barrier function tests<\/a>, and we perform concurrent treatments to protect the skin barrier.<br\/><\/p>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-0958e68c wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">Initial Visit<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-049d8620 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-white-background-color has-background is-layout-flow wp-container-core-column-is-layout-9dd55f02 wp-block-column-is-layout-flow\" style=\"border-top-left-radius:16px;border-top-right-radius:16px;border-bottom-left-radius:16px;border-bottom-right-radius:16px;padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:var(--wp--preset--spacing--superbspacing-xsmall);padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:var(--wp--preset--spacing--superbspacing-xsmall)\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/02\/mast-allergy-test-report.png\" alt=\"This is a MAST acute allergy test report conducted during the initial atopic dermatitis visit, providing an at-a-glance view of serum IgE responses to major allergens such as house dust mites, pollen, and food.\" class=\"wp-image-4075\"\/><figcaption class=\"wp-element-caption\">MAST Test<\/figcaption><\/figure>\n\n\n\n<p class=\"has-custom-color-3-color has-text-color has-link-color has-superbfont-medium-font-size wp-elements-1a2bda7c4f3e6fb53e602087dc51231a wp-block-paragraph\"><strong>1. Acute Allergy Test<\/strong><\/p>\n\n\n\n<p class=\"has-superbfont-small-font-size wp-block-paragraph\">Identifying factors that cause inflammation<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-white-background-color has-background is-layout-flow wp-container-core-column-is-layout-9dd55f02 wp-block-column-is-layout-flow\" style=\"border-top-left-radius:16px;border-top-right-radius:16px;border-bottom-left-radius:16px;border-bottom-right-radius:16px;padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:var(--wp--preset--spacing--superbspacing-xsmall);padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:var(--wp--preset--spacing--superbspacing-xsmall)\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/02\/patch-test-forearm.png\" alt=\"This image shows a patch test performed during the initial atopic dermatitis visit, where patches are applied under a transparent film on the inner arm to check for delayed allergic reactions to Protopic\/Elidel ointments and MD moisturizing creams.\" class=\"wp-image-4122\"\/><figcaption class=\"wp-element-caption\">Patch Test<\/figcaption><\/figure>\n\n\n\n<p class=\"has-custom-color-3-color has-text-color has-link-color has-superbfont-medium-font-size wp-elements-05bd2d4820377c690d9b356b9acbb10d wp-block-paragraph\"><strong>2. Delayed Allergy Test<\/strong><\/p>\n\n\n\n<p class=\"has-superbfont-small-font-size wp-block-paragraph\">Identifying sensitivity to Protopic, Elidel, and MD creams<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-white-background-color has-background is-layout-flow wp-container-core-column-is-layout-9dd55f02 wp-block-column-is-layout-flow\" style=\"border-top-left-radius:16px;border-top-right-radius:16px;border-bottom-left-radius:16px;border-bottom-right-radius:16px;padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:var(--wp--preset--spacing--superbspacing-xsmall);padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:var(--wp--preset--spacing--superbspacing-xsmall)\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/02\/tewl-measurement-device-2.png\" alt=\"This scene shows a transepidermal water loss (TEWL) measurement performed during the initial atopic dermatitis visit, where a rose gold sensor probe is placed against the skin to quantitatively assess the extent of skin barrier dysfunction.\" class=\"wp-image-4123\"\/><figcaption class=\"wp-element-caption\">TEWL Measurement<\/figcaption><\/figure>\n\n\n\n<p class=\"has-custom-color-3-color has-text-color has-link-color has-superbfont-medium-font-size wp-elements-f895d8360b1b5f29ad1bcef810948e3e wp-block-paragraph\"><strong>3. Skin Barrier Function Test<\/strong><\/p>\n\n\n\n<p class=\"has-superbfont-small-font-size wp-block-paragraph\">Assessing the extent of damage to the skin barrier, which protects against external irritants<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-white-background-color has-background is-layout-flow wp-container-core-column-is-layout-9dd55f02 wp-block-column-is-layout-flow\" style=\"border-top-left-radius:16px;border-top-right-radius:16px;border-bottom-left-radius:16px;border-bottom-right-radius:16px;padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:var(--wp--preset--spacing--superbspacing-xsmall);padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:var(--wp--preset--spacing--superbspacing-xsmall)\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/02\/nda-plus-skin-application.png\" alt=\"This scene depicts the application of a transparent liquid wound dressing to the inner arm using a pen-type applicator during the initial atopic dermatitis visit, a treatment process designed to protect the damaged skin barrier and promote recovery.\" class=\"wp-image-4124\"\/><figcaption class=\"wp-element-caption\">Application of Wound Dressing<\/figcaption><\/figure>\n\n\n\n<p class=\"has-custom-color-3-color has-text-color has-link-color has-superbfont-medium-font-size wp-elements-e947e1dfef23bff20996ba679f58cf4a wp-block-paragraph\"><strong>4. Skin Barrier Improvement<\/strong><\/p>\n\n\n\n<p class=\"has-superbfont-small-font-size wp-block-paragraph\">Protecting the skin barrier with wound dressing<\/p>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Second Visit<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-049d8620 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-white-background-color has-background is-layout-flow wp-container-core-column-is-layout-9dd55f02 wp-block-column-is-layout-flow\" style=\"border-top-left-radius:16px;border-top-right-radius:16px;border-bottom-left-radius:16px;border-bottom-right-radius:16px;padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:var(--wp--preset--spacing--superbspacing-xsmall);padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:var(--wp--preset--spacing--superbspacing-xsmall)\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/02\/face-washing.png\" alt=\"This demonstrates the correct face-washing technique taught during the second atopic dermatitis visit, showing how to gently rinse the face with water in both hands to minimize skin irritation through improved lifestyle habits.\" class=\"wp-image-4130\"\/><\/figure>\n\n\n\n<p class=\"has-custom-color-3-color has-text-color has-link-color has-superbfont-medium-font-size wp-elements-c46d5a73d5954fc0b113b6f6f7200b0b wp-block-paragraph\"><strong>1. Guidance on Lifestyle Improvements<\/strong><\/p>\n\n\n\n<p class=\"has-superbfont-small-font-size wp-block-paragraph\">Providing guidance on improving the living environment based on test results<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-white-background-color has-background is-layout-flow wp-container-core-column-is-layout-9dd55f02 wp-block-column-is-layout-flow\" style=\"border-top-left-radius:16px;border-top-right-radius:16px;border-bottom-left-radius:16px;border-bottom-right-radius:16px;padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:var(--wp--preset--spacing--superbspacing-xsmall);padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:var(--wp--preset--spacing--superbspacing-xsmall)\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/02\/providing-moisturizer-samples.png\" alt=\"This shows the provision of Aestura Atobarrier Cream and Zeroid Intensive Rich Cream MD sample pouches to a patient during the second atopic dermatitis visit, after confirming no sensitivity in the patch test.\" class=\"wp-image-4125\"\/><\/figure>\n\n\n\n<p class=\"has-custom-color-3-color has-text-color has-link-color has-superbfont-medium-font-size wp-elements-5d6efb176d0f7e68dc3a84789c8ed575 wp-block-paragraph\"><strong>2. Provision of MD Cream Samples<\/strong><\/p>\n\n\n\n<p class=\"has-superbfont-small-font-size wp-block-paragraph\">Providing samples of MD creams that showed no sensitivity<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-white-background-color has-background is-layout-flow wp-container-core-column-is-layout-9dd55f02 wp-block-column-is-layout-flow\" style=\"border-top-left-radius:16px;border-top-right-radius:16px;border-bottom-left-radius:16px;border-bottom-right-radius:16px;padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:var(--wp--preset--spacing--superbspacing-xsmall);padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:var(--wp--preset--spacing--superbspacing-xsmall)\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/02\/itemized-medical-bill-2.png\" alt=\"This is a detailed medical bill for atopic dermatitis treatment covered by health insurance, listing the initial consultation fee and the prescription for Atobarrier Cream MD, illustrating the process of receiving insurance-covered treatment.\" class=\"wp-image-4128\"\/><\/figure>\n\n\n\n<p class=\"has-custom-color-3-color has-text-color has-link-color has-superbfont-medium-font-size wp-elements-2d38f069038c0c7ff30def6875f6d96e wp-block-paragraph\"><strong>3. Ointment Prescription<\/strong><\/p>\n\n\n\n<p class=\"has-superbfont-small-font-size wp-block-paragraph\">Managing inflammation, Demodex mites, and fungi as needed using non-sensitizing ointments<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-white-background-color has-background is-layout-flow wp-container-core-column-is-layout-9dd55f02 wp-block-column-is-layout-flow\" style=\"border-top-left-radius:16px;border-top-right-radius:16px;border-bottom-left-radius:16px;border-bottom-right-radius:16px;padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:var(--wp--preset--spacing--superbspacing-xsmall);padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:var(--wp--preset--spacing--superbspacing-xsmall)\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/02\/nda-plus-skin-application.png\" alt=\"This scene shows the repeated application of wound dressing using a pen-type applicator during the second atopic dermatitis visit to continuously protect the skin barrier and promote healing, highlighting the importance of consistent barrier management.\" class=\"wp-image-4124\"\/><\/figure>\n\n\n\n<p class=\"has-custom-color-3-color has-text-color has-link-color has-superbfont-medium-font-size wp-elements-e947e1dfef23bff20996ba679f58cf4a wp-block-paragraph\"><strong>4. Skin Barrier Improvement<\/strong><\/p>\n\n\n\n<p class=\"has-superbfont-small-font-size wp-block-paragraph\">Protecting the skin barrier with wound dressing<br\/><br\/><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sec-conclusion\">Conclusion<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Atopic dermatitis is a <strong>chronic inflammatory disease that begins with skin barrier damage<\/strong>. Once the barrier is restored and external irritants can no longer penetrate easily, you can become relatively free from the various restrictions mentioned above. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Therefore, our treatment goal is not temporary relief of atopic symptoms, but the <strong>reconstruction of a strong &#8216;skin fortress&#8217; that protects itself<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-dots\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"&#xCC38;&#xACE0;-&#xBB38;&#xD5CC;\">References<\/h3>\n\n\n\n<ol class=\"wp-block-list has-custom-color-5-color has-text-color has-link-color has-superbfont-xxsmall-font-size wp-elements-22ffb6dd185fdf397b592e82bb47e6cb\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18329087\/\" target=\"_blank\" rel=\"noopener\"><em>Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol. 2008;121(6):1337-1343.   <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16550169\/\" target=\"_blank\" rel=\"noopener\"><em>Palmer CN, Irvine AD, Terron-Kwiatkowski A, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38(4):441-446.   <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18539191\/\" target=\"_blank\" rel=\"noopener\"><em>Lack G. Epidemiologic risks for food allergy. J Allergy Clin Immunol. 2008;121(6):1331-1336.  <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22293182\/\" target=\"_blank\" rel=\"noopener\"><em>Kubo A, Nagao K, Amagai M. Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. J Clin Invest. 2012;122(2):440-7.  <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11551248\/\" target=\"_blank\" rel=\"noopener\"><em>Schmid-Grendelmeier P, Simon D, Simon HU, et al. Epidemiology, clinical features, and immunology of the intrinsic (non-IgE-mediated) type of atopic dermatitis (constitutional dermatitis). Allergy. 2001;56(9):841-849.   <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25705822\/\" target=\"_blank\" rel=\"noopener\"><em>Du Toit G, Roberts G, Sayre PH, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372(9):803-813.  <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24688624\/\" target=\"_blank\" rel=\"noopener\"><em>Katta R, Schlichte M. Diet and dermatitis: food triggers. J Clin Aesthet Dermatol. 2014;7(3):30-36.  <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25396122\/\" target=\"_blank\" rel=\"noopener\"><em>Coondoo A, Phiske M, Verma S, et al. Side-effects of topical steroids: A long overdue revisit. Indian Dermatol Online J. 2014;5(4):416-425.  <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21974750\/\" target=\"_blank\" rel=\"noopener\"><em>Czarnecka-Operacz M, Jenerowicz D. Topical calcineurin inhibitors in the treatment of atopic dermatitis \u2013 an update on safety issues. J Dtsch Dermatol Ges. 2012;10(3):167-172.  <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24094650\/\" target=\"_blank\" rel=\"noopener\"><em>Wilson SR, Th\u00e9 L, Batia LM, et al. The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell. 2013;155(2):285-295.   <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23450580\/\" target=\"_blank\" rel=\"noopener\"><em>Apfelbacher CJ, van Zuuren EJ, Fedorowicz Z, et al. Oral H1 antihistamines as monotherapy for eczema. Cochrane Database Syst Rev. 2013;(2):CD007770.<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30666626\/\" target=\"_blank\" rel=\"noopener\"><em>Matterne U, B\u00f6hmer MM, Weisshaar E, et al. Oral H1 antihistamines as &#8216;add-on&#8217; therapy to topical treatment for eczema. Cochrane Database Syst Rev. 2019;(1):CD012167.<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2110817\/\" target=\"_blank\" rel=\"noopener\"><em>Wahlgren CF, H\u00e4germark \u00d6, Bergstr\u00f6m R. The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis. Br J Dermatol. 1990;122(4):545-551.  <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10606058\/\" target=\"_blank\" rel=\"noopener\"><em>Klein PA, Clark RA. An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Arch Dermatol. 1999;135(12):1522-1525.   <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26512171\/\" target=\"_blank\" rel=\"noopener\"><em>Kim JE, et al. Consensus guidelines for the treatment of atopic dermatitis in Korea (Part I). Ann Dermatol. 2015;27(5):563-577.   <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16815133\/\" target=\"_blank\" rel=\"noopener\"><em>Cork MJ, Robinson DA, Vasilopoulos Y, et al. New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. J Allergy Clin Immunol. 2006;118(1):3-21; quiz 22-3.   <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30053491\/\" target=\"_blank\" rel=\"noopener\"><em>Rastogi S, Patel KR, Singam V, et al. Allergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis. J Am Acad Dermatol. 2018;79(6):1028-1033.e6.   <\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35759448\/\" target=\"_blank\" rel=\"noopener\"><em>Tanzer J, Meng D, Ohsaki A, et al. Laundry detergent promotes allergic skin inflammation and esophageal eosinophilia in mice. PLoS One. 2022;17(6):e0268651.<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25207685\/\" target=\"_blank\" rel=\"noopener\"><em>Cheng J, Zug KA. Fragrance allergic contact dermatitis. Dermatitis. 2014;25(5):232-245.   <\/em><\/a><\/li>\n<\/ol>\n\n<\/div>\n\n<div class=\"wp-block-group has-custom-color-6-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-353751c3 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--superbspacing-xlarge);padding-right:var(--wp--preset--spacing--superbspacing-small);padding-bottom:var(--wp--preset--spacing--superbspacing-xlarge);padding-left:var(--wp--preset--spacing--superbspacing-small)\">\n<h2 class=\"wp-block-heading\" id=\"&#xC790;&#xC8FC;-&#xBB3B;&#xB294;-&#xC9C8;&#xBB38;\">Frequently Asked Questions<\/h2>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-1\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can atopic dermatitis be cured?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>The fundamental cause of atopic dermatitis is a weak skin barrier. When the skin barrier becomes strong, external irritants cannot penetrate, leading to improved symptoms; this state can be maintained long-term unless a specific event occurs. Furthermore, pediatric atopic dermatitis often improves naturally as the skin barrier matures with growth. Adults can also maintain a symptom-free state by removing the causes of barrier damage (such as steroid misuse, excessive skin procedures, and irritating cosmetics) and through consistent management.   <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-2\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">I still itch even after taking antihistamines for atopic dermatitis. Why is that? <\/h3>\n<div class=\"rank-math-answer \">\n\n<p>This is because the itch of atopic dermatitis is driven by pathways such as IL-31 and TSLP, rather than histamine. Antihistamines are effective for itching caused by histamine, such as hives, but their direct effect on the itching associated with this condition has not been proven. While the drowsiness caused by 1st-generation (sedative) antihistamines may indirectly help reduce nighttime scratching, it does not reduce the itch itself.  <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-3\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">What is a good moisturizer for atopic dermatitis?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Because everyone&#8217;s skin is different, a &#8216;good moisturizer&#8217; varies by individual. Due to the nature of this condition where the skin barrier is weak, moisturizers are very helpful; however, in a state where the barrier is weak, the moisturizer can seep into the skin and worsen inflammation. Therefore, the key is to find a product that suits you. At our clinic, we check the sensitivity of various MD creams through patch testing and provide samples of safe products. When choosing one yourself without a test, select a product with a short ingredient list and test it on the affected area for at least 3 days.    <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-4\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Does applying steroid ointment for a long time thin the skin?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes, long-term use of steroid ointments can weaken the skin barrier and cause skin thinning. Areas with thin skin, such as the face, are at a higher risk of side effects. However, by using an appropriate grade of product at a sufficient intensity for a short period and then gradually reducing it (tapering), you can effectively control inflammation while minimizing side effects.  <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-5\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">My child has atopy; is it okay to feed them eggs and milk?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Unless there are severe allergic reactions such as vomiting or hives, it is actually important to introduce them in small amounts. Since childhood is a period when the immune system &#8216;creates a list of citizens versus the mafia,&#8217; the immune system must be educated to recognize food entering the digestive tract as a safe substance (immune tolerance). In a study of 640 subjects, the group with early peanut consumption had an approximately 81% lower incidence of allergies compared to the avoidance group. Excessive dietary restriction can actually increase the risk of allergies and hinder growth.   <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-6\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Are atopy and allergies the same thing?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No, they are not. Atopy, which occurs due to a weak skin barrier, is the cause, and an allergy is the result. When external substances penetrate through gaps in a weakened skin barrier, the immune system recognizes them as dangerous; subsequently, an allergic reaction occurs even when the same substance enters through food or respiration. However, not all patients have allergies; approximately 20% have &#8216;intrinsic&#8217; atopy, which involves skin barrier issues without allergies.   <\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"wp-block-cover is-light\" style=\"padding-top:var(--wp--preset--spacing--superbspacing-xlarge);padding-right:var(--wp--preset--spacing--superbspacing-small);padding-bottom:var(--wp--preset--spacing--superbspacing-xlarge);padding-left:var(--wp--preset--spacing--superbspacing-small)\"><img decoding=\"async\" class=\"wp-block-cover__image-background wp-image-2284 size-large\" alt=\"\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/01\/decorative-plant-background.jpg\" data-object-fit=\"cover\"\/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\" style=\"background-color:#c8cdc3\"><\/span><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-container-core-cover-is-layout-04736a1c wp-block-cover-is-layout-constrained\">\n<div class=\"wp-block-group alignwide mobile-only has-custom-color-2-background-color has-background is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-f0f9e475 wp-block-group-is-layout-flex\" style=\"border-style:none;border-width:0px;border-radius:20px;margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--superbspacing-xlarge);padding-right:0;padding-bottom:var(--wp--preset--spacing--superbspacing-xlarge);padding-left:0\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-fdc69663 wp-block-group-is-layout-constrained\" style=\"padding-right:var(--wp--preset--spacing--superbspacing-small);padding-left:var(--wp--preset--spacing--superbspacing-small)\">\n<p class=\"has-text-align-center has-custom-color-4-color has-text-color has-link-color has-superbfont-large-font-size wp-elements-ee04e0b6278e5532b13056c376ad6809 wp-block-paragraph\" style=\"font-style:normal;font-weight:600;line-height:1.2\">Ready to get back to your daily life?<br\/>Start now.<\/p>\n\n\n\n<p class=\"has-text-align-center has-custom-color-5-color has-text-color has-link-color wp-elements-fb12d5cc08f68f75bb3c2b6d325389a8 wp-block-paragraph\">If you have indemnity insurance,<br\/>you can get started without \ubd80\ub2f4.<br\/>Resolve your questions first with a free consultation.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-vertical is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-51c7b669 wp-block-buttons-is-layout-flex\" style=\"padding-right:0;padding-left:0\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-custom-color-1-color has-custom-color-4-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/booking.naver.com\/booking\/16\/bizes\/1617588\" style=\"border-style:none;border-width:0px\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Naver Booking<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-outline is-style-outline--2\"><a class=\"wp-block-button__link has-custom-color-9-color has-text-color has-link-color has-border-color has-custom-color-4-border-color wp-element-button\" href=\"https:\/\/pf.kakao.com\/_lnrxhn\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">KakaoTalk Consultation<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Conditions Atopic Dermatitis | Why does it occur and how is it treated? 1. Causes of Atopic Dermatitis Atopic dermatitis is a condition that occurs when the skin barrier is weak, allowing external irritants to penetrate the skin.1 Congenital or acquired barrier defects are the starting point. As the barrier breaks down, the immune response [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":11982,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-full-width","meta":{"_miragen_jsonld":"","footnotes":""},"class_list":["post-11966","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/pages\/11966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/comments?post=11966"}],"version-history":[{"count":8,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/pages\/11966\/revisions"}],"predecessor-version":[{"id":12001,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/pages\/11966\/revisions\/12001"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/media\/11982"}],"wp:attachment":[{"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/media?parent=11966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}