{"id":12170,"date":"2026-03-21T16:20:04","date_gmt":"2026-03-21T07:20:04","guid":{"rendered":"https:\/\/miragen.clinic\/atobarrier-itching-cream\/"},"modified":"2026-07-10T21:29:25","modified_gmt":"2026-07-10T12:29:25","slug":"atobarrier-itching-cream","status":"publish","type":"page","link":"https:\/\/miragen.clinic\/en\/atobarrier-itching-cream\/","title":{"rendered":"Atobarrier Itching Cream"},"content":{"rendered":"\n<div class=\"wp-block-group has-custom-color-4-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-e96bc7c8 wp-block-group-is-layout-constrained\" style=\"padding-top:240px;padding-right:var(--wp--preset--spacing--superbspacing-small);padding-bottom:240px;padding-left:var(--wp--preset--spacing--superbspacing-small)\">\n<p class=\"has-custom-color-6-color has-text-color has-link-color wp-elements-a7c9d84906edddaaa65d240c711daaa3 wp-block-paragraph\">Medications<\/p>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-left has-custom-color-1-color has-text-color has-link-color wp-elements-95a48a604567cba8c6d42bd37eafc45f\">Atobarrier Itching Cream | A moisturizer that reduces the burning sensation from Protopic and neurogenic rosacea<\/h1>\n<\/div>\n\n<div class=\"wp-block-group has-custom-color-2-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-1b17c90e wp-block-group-is-layout-constrained\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--superbspacing-xlarge);padding-right:var(--wp--preset--spacing--superbspacing-small);padding-bottom:var(--wp--preset--spacing--superbspacing-xlarge);padding-left:var(--wp--preset--spacing--superbspacing-small)\">\n<p class=\"wp-block-paragraph\">Atobarrier Itching Cream is a cream that inhibits the heat sensor (TRPV1) in the skin\u2019s sensory nerves. It helps reduce the burning sensation and worsening redness that can occur early on when using <a href=\"https:\/\/miragen.clinic\/en\/protopic\/\" data-type=\"page\" data-id=\"6419\">Protopic<\/a> and <a href=\"https:\/\/miragen.clinic\/en\/elidel\/\" data-type=\"page\" data-id=\"6418\">Elidel<\/a>, and may also help relieve the burning sensation and redness of neurogenic rosacea.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block has-custom-color-5-color has-custom-color-11-background-color has-text-color has-background has-link-color wp-elements-09cca45ab162e629f9bea29b7e0dfffb\" style=\"padding-top:var(--wp--preset--spacing--superbspacing-xsmall);padding-right:0;padding-bottom:var(--wp--preset--spacing--superbspacing-xsmall);padding-left:0\" id=\"rank-math-toc\"><h2>\ubaa9\ucc28<\/h2><nav><ul><li><a href=\"#sec-1\">1. What is Atobarrier Itching Cream?<\/a><\/li><li><a href=\"#sec-2\">2. How does it work?<\/a><\/li><li><a href=\"#sec-3\">3. Why use it with Protopic \u00b7 Elidel<\/a><\/li><li><a href=\"#sec-4\">4. Clinical evidence<\/a><\/li><li><a href=\"#sec-5\">5. How to use<\/a><\/li><li><a href=\"#sec-6\">6. Conclusion<\/a><\/li><li><a href=\"#sec-faq\">Frequently Asked Questions<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"sec-1\" class=\"wp-block-heading\">1. What is Atobarrier Itching Cream?<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Atobarrier Itching Cream is a cream whose main ingredient is <strong>Asivatrep<\/strong>, developed by Amorepacific. Its official name is Atobarrier Itching Cream MD, and it is classified as a medical device. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Asivatrep is a substance that selectively blocks the skin\u2019s sensory-nerve <strong>heat sensor (TRPV1)<\/strong>. TRPV1 is a receptor activated by heat that triggers itching, burning, and redness, and it is overexpressed in atopic dermatitis and rosacea.<sup><a style=\"color: inherit;\" href=\"#&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\">1<\/a>,<a style=\"color: inherit;\" href=\"#&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\">2<\/a><\/sup> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Within the same Atobarrier line, the moisturizing power is in the order of <strong>Aestura Cream (richest) &gt; Atobarrier Cream &gt; Itching Cream<\/strong>.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"5504\" height=\"3072\" src=\"https:\/\/miragen.clinic\/wp-content\/uploads\/2026\/03\/atobarrier-itching-cream-product.png\" alt=\"Product photo of Atobarrier Itching Cream 160 g tube. A cream containing Asivatrep, a TRPV1-inhibiting ingredient, to relieve the early burning sensation from Protopic &#xB7; Elidel use and redness in neurogenic rosacea \" class=\"wp-image-9348\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"sec-2\" class=\"wp-block-heading\">2. How does it work?<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">The key mechanism of Itching Cream is blocking TRPV1. This simultaneously suppresses two pathways. <\/p>\n\n\n\n<ul class=\"wp-block-list has-custom-color-5-color has-text-color has-link-color wp-elements-768bf79492d02570752f1dabce24a583\">\n<li><strong>Suppresses itching \u00b7 burning<\/strong> \u2014 reduces substance P release<sup><a style=\"color: inherit;\" href=\"#&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\">3<\/a><\/sup><\/li>\n\n\n\n<li><strong>Suppresses redness<\/strong> \u2014 reduces CGRP release \u2192 inhibits vasodilation<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">In neurogenic rosacea, TRPV1 is overexpressed, so even everyday stimuli can trigger CGRP release, causing burning and redness.<sup><a style=\"color: inherit;\" href=\"#&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\">1<\/a>,<a style=\"color: inherit;\" href=\"#&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\">4<\/a><\/sup> Blocking TRPV1 may help relieve these symptoms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"sec-3\" class=\"wp-block-heading\">3. Why use it with Protopic \u00b7 Elidel<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Protopic and Elidel <strong>stimulate<\/strong> TRPV1, triggering the release of substance P and CGRP.<sup><a style=\"color: inherit;\" href=\"#&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\">5<\/a><\/sup> This is why itching, burning, and redness can worsen early on.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By inhibiting TRPV1 with Itching Cream, neuropeptide release decreases, minimizing early symptom worsening. Therefore, if irritation is severe even when used together, contact dermatitis may be suspected. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The anti-inflammatory effects of Protopic \u00b7 Elidel work through calcineurin inhibition and are independent of the TRPV1 pathway. Therefore, Itching Cream does not interfere with the treatment effect. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"sec-4\" class=\"wp-block-heading\">4. Clinical evidence<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Asivatrep has undergone Phase 2 and Phase 3 clinical trials for atopic dermatitis.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Phase 2<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In two Phase 2 trials in patients with mild-to-moderate atopic dermatitis, the efficacy and safety of Asivatrep cream were confirmed.<sup><a style=\"color: inherit;\" href=\"#&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\">6<\/a>,<a style=\"color: inherit;\" href=\"#&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\">7<\/a><\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Phase 3 \u2014 CAPTAIN-AD<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In CAPTAIN-AD, a large randomized controlled trial, Asivatrep 1% cream showed a meaningful improvement in mild-to-moderate atopic dermatitis. Both the IGA (Investigator&#8217;s Global Assessment) success rate and the EASI (Eczema Area and Severity Index) improvement rate showed statistically significant differences versus placebo.<sup><a style=\"color: inherit;\" href=\"#&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\">8<\/a><\/sup> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In particular, because it works via a different mechanism (TRPV1 blockade) than steroids or calcineurin inhibitors, it is meaningful in that it can be used in combination with existing treatments or as an alternative.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"sec-5\" class=\"wp-block-heading\">5. How to use<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<ul class=\"wp-block-list has-custom-color-5-color has-text-color has-link-color wp-elements-831da8cdcbbfaf94f1a1e4d6e376133c\">\n<li>Apply twice daily, morning and evening.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"sec-6\" class=\"wp-block-heading\">6. Conclusion<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Atobarrier Itching Cream blocks TRPV1 to minimize early itching, burning, and redness from Protopic \u00b7 Elidel, and to relieve the burning sensation and redness of neurogenic rosacea. It can also serve as a moisturizer, and it does not interfere with anti-inflammatory effects even when used with calcineurin inhibitors. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-dots\"\/>\n\n\n\n<h3 id=\"&#xCC38;&#xACE0;&#xBB38;&#xD5CC;\" class=\"wp-block-heading\">References<\/h3>\n\n\n\n<ol class=\"wp-block-list has-custom-color-5-color has-text-color has-link-color has-superbfont-xxsmall-font-size wp-elements-8bdafe4a0ea0681e88ad5949a104aafc\">\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22189789\/\" target=\"_blank\" rel=\"noopener\"><em>Sulk M, Seeliger S, Aubert J, et al. Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. J Invest Dermatol. 2012;132(4):1253-62.   <\/em><\/a><\/li>\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31620803\/\" target=\"_blank\" rel=\"noopener\"><em>Park J, Bhatt DK, Engstr\u00f6m M, et al. Immunohistochemical evaluation of TRPV1 in rosacea skin. Acta Derm Venereol. 2019;99(13):1300-1301.   <\/em><\/a><\/li>\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29752146\/\" target=\"_blank\" rel=\"noopener\"><em>Lee YW, Won CH, Jung K, et al. Efficacy and safety of PAC-14028 cream \u2014 a novel, topical, nonsteroidal, selective TRPV1 antagonist in patients with mild-to-moderate atopic dermatitis. J Dermatol Sci. 2018;91(3):289-296.   <\/em><\/a><\/li>\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37606610\/\" target=\"_blank\" rel=\"noopener\"><em>Lee J, Kim MJ, Park S, et al. Demodex and rosacea: TRPV1-NGF-TRKA pathway in neurogenic inflammation. J Eur Acad Dermatol Venereol. 2023;37(12):2449-2459.   <\/em><\/a><\/li>\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28253495\/\" target=\"_blank\" rel=\"noopener\"><em>Haerer W, Bhatt DK, Bhatt R, et al. Tacrolimus directly activates TRPV1. Pharmacology. 2017;99(3-4):179-185.   <\/em><\/a><\/li>\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31025744\/\" target=\"_blank\" rel=\"noopener\"><em>Song K, Hou XY, Chen YJ, et al. Phase 2 trial of PAC-14028 cream for mild-to-moderate atopic dermatitis. Br J Dermatol. 2019;181(5):1014-1022.   <\/em><\/a><\/li>\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30623408\/\" target=\"_blank\" rel=\"noopener\"><em>Lee JH, Won CH, Jung K, et al. Phase 2 randomized trial of PAC-14028 cream. Br J Dermatol. 2019;180(5):1202-1210.   <\/em><\/a><\/li>\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34606832\/\" target=\"_blank\" rel=\"noopener\"><em>Park CW, Kim BJ, Lee YW, et al. Asivatrep, a TRPV1 antagonist, for the topical treatment of atopic dermatitis: Phase 3, randomized clinical trial (CAPTAIN-AD). J Allergy Clin Immunol. 2022;149(4):1340-1347.e4.   <\/em><\/a><\/li>\n\n<\/ol>\n<\/div>\n\n<div class=\"wp-block-group has-custom-color-6-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-4c3b03bf wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--superbspacing-xlarge);padding-right:var(--wp--preset--spacing--superbspacing-small);padding-bottom:var(--wp--preset--spacing--superbspacing-xlarge);padding-left:var(--wp--preset--spacing--superbspacing-small)\">\n<h2 id=\"sec-faq\" class=\"wp-block-heading\">Frequently Asked Questions<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-color-5-color has-alpha-channel-opacity has-custom-color-5-background-color has-background is-style-wide\" style=\"margin-top:var(--wp--preset--spacing--superbspacing-xsmall);margin-bottom:var(--wp--preset--spacing--superbspacing-xsmall)\"\/>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-0000000001\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Do I need a prescription for Itching Cream?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Itching Cream is classified as a medical device, so it can be purchased without a prescription. However, to file a claim for indemnity insurance, you must purchase it after receiving a prescription. <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-0000000002\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can I use only Itching Cream on its own?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes. If itching or a burning sensation is your main symptom, it can be used on its own. However, if inflammation is also present, it is more effective to use it together with an anti-inflammatory treatment such as Protopic or Elidel.  <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-0000000003\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">How many times a day should I apply it?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Typically, apply it twice daily (morning and evening). When using it with Protopic or Elidel, apply Itching Cream first after washing your face in the evening, then apply the treatment on top. <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-0000000004\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can I use it with a steroid ointment?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes. Itching Cream can be used together with steroids because it works through a different pathway. <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-0000000005\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">How long can I use it?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>It does not weaken the skin barrier like steroids, so it can be used long term.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-0000000006\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can I claim indemnity insurance (medical expense insurance)?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes. If you purchase it after receiving a prescription at the clinic, you can file an indemnity insurance claim. If you purchase it directly without a prescription, it is difficult to file a claim.  <\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Medications Atobarrier Itching Cream | A moisturizer that reduces the burning sensation from Protopic and neurogenic rosacea Atobarrier Itching Cream is a cream that inhibits the heat sensor (TRPV1) in the skin\u2019s sensory nerves. It helps reduce the burning sensation and worsening redness that can occur early on when using Protopic and Elidel, and may [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":12171,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-full-width","meta":{"_miragen_jsonld":"","footnotes":""},"class_list":["post-12170","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/pages\/12170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/comments?post=12170"}],"version-history":[{"count":5,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/pages\/12170\/revisions"}],"predecessor-version":[{"id":13057,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/pages\/12170\/revisions\/13057"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/media\/12171"}],"wp:attachment":[{"href":"https:\/\/miragen.clinic\/en\/wp-json\/wp\/v2\/media?parent=12170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}